Bioquímica y Biofísica molecular – Publicaciones


  • Miguel V, Sánchez-Borzone M, Mariani ME and García DA. Modulation of membrane physical properties by natural insecticidal ketones. Biophysical Chemistry, 1      269, 106526 (2021) (ISSN: 0301-4622)


  • Verónica Nolan, Alejandro Colin, Carolina Rodriguez and María Angélica Perillo. “Effect of Polyethylene Glycol-Induced Molecular Crowding on the Enzymatic Activity and Thermal Stability of β‑Galactosidase from Kluyveromyces lactis”. Journal of Agricultural and Food Chemistry. (2020) 68: 8875-8882. IF: 4,192; Q1.
  • Julieta M. Sánchez, Hector Lopez-Laguna, Patricia Álamo, Naroa Serna, Alejandro Sánchez-Chardi, Verónica Nolan, Olivia Cano-Garrido, Isolda Casanova, Ugutz Unzueta, Esther Vazquez, Ramon Mangues and Antonio Villaverde. “Artificial inclusion bodies for clinical development”. Advanced Science, (2020) 7: 1902420. IF: 15.80; Q1
  • Uppar1 V, Chandrashekharappa S, Venugopala KN, Kishore Deb P, Kar S, Alwassil OI, Gleiser RM, Garcia D, Odhav b, Mohan MK, Venugopala R and Padmashali B. Synthesis and characterization of pyrrolo[1,2-a]quinoline derivatives for their larvicidal activity against Anopheles arabiensis. Structural Chemistry, 31, 1533–1543 (2020) (ISSN: 1572-9001)
  • Felsztyna I, Sánchez-Borzone M, Miguel V and García DA. The insecticide Fipronil affects the physical properties of model membranes: A combined experimental and molecular dynamics simulations study in Langmuir monolayers. Biochimica et Biophysica Acta, Biomembranes. 1862(10), 183378 (2020) (ISSN: 0005-2736).
  • Iván Felsztyna, Anahí V Turina, Maria A Perillo, Eduardo M. Clop. (2020) Sensing molecular organizational changes through the catalytic activity of acethylcholinesterase from erythrocyte membranes in Langmuir-Blodgett films. Biochimica et Biophisical Acta. 1862:183188. ISSN: 0005-2736.
  • Giojalas LC, Guidobaldi HA, Cragnolini AB, Franchi AN, Garcia Romano L, Bermudez GMA, Danelon V, Moreno Irusta A, Domínguez EM, Figueras López Understanding new molecular and cell biology findings based on progressive scientific practices and interconnected activities in undergraduate students. MJ.Biochem Mol Biol Educ. 2020 Aug 21.
  • Cragnolini AB*, Lampitella G*, Virtuoso A, Viscovo I, Panetsos F, Papa M, Cirillo G. Regional brain susceptibility to neurodegeneration: what is the role of glial cells? Neural Regeneration Research. 2020 May;15(5):838-842. *co-authors.


  • MI Burgos, A Ochoa, MA Perillo. β-sheet to α-helix conversion and thermal stability of β-Galactosidase encapsulated in a nanoporous silica gel. Biochemical and biophysical research (2019) 508: 270-274
  • Verónica Nolan, Pedro Clop, Inés Burgos and María A. Perillo. “Dual substrate/solvent-roles of water and mixed reaction-diffusion control of b-Galactosidase catalyzed reactions in PEG-induced macromolecular crowding conditions”. Biochemical and Biophysical Research Communication. (2019) 515: 190-195. IF: 2.559; Q1
  • Sandra S Flores, Verónica Nolan, María A. Perillo and Julieta M. Sánchez. “Superactive b-Galactosidase inclusion bodies”. Colloids and Surfaces B (2019) 173: 769-775. IF: 3.997; Q1
  • Miguel V, Villarreal M and García DA. Effects of gabergic phenols on the dynamic and structure of lipid bilayers. A molecular dynamic simulation approach. Plos One, 14(6), e0218042 (2019) (ISSN: 1932-6203) https: //
  • Montroull LE, Danelon V, Cragnolini AB*, Mascó DH*. Loss of TrkB signaling due to status epilepticus induces a proBDNF-dependent cell death. Frontiers Cell Neurosc. 2019; 8;13:4. *co-corresponding authors.


  • Chandrashekharappa S, Venugopala KN, Nayak SK, Gleiser RM, García DA, Kumalo HM, Kulkarni RS, Mahomoodally FM, Venugopala R, Mohan MK and  Odhav B. One-pot microwave assisted synthesis and structural elucidation of novel ethyl 3-substituted-7-methylindolizine-1-carboxylates with larvicidal activity against Anopheles arabiensis. Journal of Molecular Structure, 1156, 377-384 (2018). (ISSN: 0022-2860).
  • Miguel V, Sánchez-Borzone M and García DA. Interaction of gabaergic ketones with model membranes: a molecular dynamics and experimental approach. Biochimica et Biophysica Acta, Biomembranes, 1860(8), 1563-1570 (2018). (ISSN: 0005-2736)
  • Bairagi KM, Venugopala KN, Mondal PK, Gleiser RM, Chopra D, García DA, Odhav B and Nayak SK.  Larvicidal study of tetrahydropyrimidine scaffolds against Anopheles arabiensis and structural insight by single crystal X-ray studies. Chemical Biology & Drug Design, 92(6), 1924-1932 (2018). (ISSN: 1747-0285).
  • Marisa J. López Rivilli, Anahí V. Turina, Elena A. Bignante, Victor H. Molina, María A. Perillo, Elizabeth L. Moyano, Margarita C. Briñon. (2018) Synthesis of a pyrazolo[4,3-c]quinolinone series. High affinity GABAA-R ligands and potential anxiolytics. Bioorganic & Medicinal Chemistry 26:3967-64. ISSN: 0968-0896.
  • Cragnolini AB, Montenegro G, Friedman WJ, Mascó DH. Brain-region specific responses of astrocytes to an in vitro injury and neurotrophins. Mol Cell Neurosci. 2018; 88:240-248.


  • Sánchez-Borzone M, Delgado Marín L, and García DA. Effects of insecticidal ketones present in mint plants on GABAA receptor from mammalian neurons. Pharmacognosy Magazine. 13(49), 114–117 (2017). (ISSN: 0973-1296).
  • Sánchez-Borzone M, Mariani ME, Miguel V, Gleiser R, Barthi O, Venugopala KN and García DA. Membrane effects of dihydropyrimidine analogues with larvicidal activity. Colloids and Surfaces (B). 150, 106– 113 (2017). (ISSN: 0927-7765).
  • Delgado Marín L, Sánchez-Borzone M and García DA.  Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties. Life Sciences, 175, 11-15 (2017). (ISSN: 0024-3205).


  • Burgos, M., Velasco, M., Acosta, R. et al. Environmental Topology and Water Availability Modulates the Catalytic Activity of β-Galactosidase Entrapped in a Nanosporous Silicate Matrix. Sci Rep 6, 36593 (2016).
  • Venugopala KN, Nayak SK, Gleiser RM, Sanchez-Borzone M, García DA and Odhav B. Synthesis, polymorphism and insecticidal activity of methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-carboxylate against Anopheles arabiensis mosquito. Chemical Biology & Drug Design, 88(1), 88-96 (2016). (ISSN: 1747-0285).
  • Mariani ME, Sánchez-Borzone M and García D.A. Effects of bioactive monoterpenic ketones on the membrane organization. A Langmuir film study. Chemistry and Physics of Lipids, 198, 39-45 (2016). (ISSN: 0009-3084).
  • Miguel V, Perillo MA, Villarreal MA. Improved prediction of bilayer and monolayer properties using a refined BMW-MARTINI force field. Biochim Biophys Acta. 2016 Nov;1858(11):2903-2910. doi: 10.1016/j.bbamem.2016.08.016. Epub 2016 Aug 31. PMID: 27591685.
  • Danelon V, Cragnolini AB, Mascó D. TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets. Journal of Neurology & Neuromedicine. 2016; 1(7): 31-36


  • Nolan MV, Sanchez JM and Perillo MA (2015). PEG-induced molecular crowding leads to a relaxed conformation, higher thermal stability and lower catalytic efficiency of Escherichia colib-galactosidase Coll.Surf.B: Biointerfaces.126,1202-1206, 2015 ISSN 0927-7765 (FI20154,152).
  • Turina AV, Clop PD and Perillo MA. (2015). Synaptosomal membranes-based Langmuir-Blodgett films. A platform for studies on gamma.aminobutyric acid type A receptor binding properties. Langmuir, 31, 1782-1801. ISSN 0743-7463 (FI2014384).
  • Gastón MS, Schiöth HB, de Barioglio SR, Salvatierra NA. (2015)“Gabaergic control of anxiety-like behavior, but not food intake, induced by ghrelin in the intermediate medial mesopallium of the neonatal chick”. Horm. Behav., 67: 66-72 .


  • Sánchez-Borzone M, Delgado Marín L, and García DA. Inhibitory effects of carvone isomers on the GABAA receptor in primary cultures of rat cortical neurons. Chirality, USA. 26(8), 368-372 (2014). (ISSN: 0899-0042)
  • Clop EM, Chattah AK, Perillo MA. (2014). Water and Membrane Dynamics in Suspensions of Lipid Vesicles Functionalized with Polyethylene Glycols. J.Phys.Chem. B. 118, 6150-6158. ISSN: 15206106 FI20143.377


  • Burgos MI, Velasco MI, Acosta RH and Perillo MA. Environmental topology and water availability modulates the catalytic activity of b-Galactosidase entrapped in a nanosporous silicate matrix .  enviado.
  • Caruso B., Sanchez, JM., García DA, de Paula E. and Perillo M.A. (2013). Probing the combined effect of Flunitrazepam and lidocaine on the stability and organization of bilayers lipid membranes. A differential scanning calorimetry and dynamic light scattering study. Cell Biochem.Biophys. 66:461-475. ISSN 1085-9195 FI2013 2.38
  • Corvalán NA, Kembro JM, Clop PD and Perillo MA (2013). Cholesterol favors the emergence of a long-range autocorrelated fluctuation pattern in voltage-induced ionic currents through lipid bilayers. BBA Biomembranes 1828, 1754-1764. ISSN 0005-2736 FI2014 3,431
  • Reiner G, Perillo MA and García DA. Effects of propofol and other gabaergic phenols on membrane molecular organization. Colloids and Surfaces (B). 101, 61– 67 (2013). (ISSN: 0927-7765).
  • Reiner G, Delgado-Marín L, Olguín N, Sánchez-Borzone M, Sánchez-Redondo S, Rodriguez Farré E, Suñol C and García DA (2013). Gabaergic pharmacological activity of propofol related compounds as possible enhancers of general anesthetics and interaction with membranes. Cell Biochemistry and Biophysics, USA. 67(2), 515–525 . (ISSN: 1085-9195).
  • Nari A., Cid M.P., Comín R., Reyna R., Juri G., Taborda R., Salvatierra N.A(2013). “Preparación de una matriz extracelular tridimensional por descelularización de hígados de conejos”. Rev. Esp. Enferm Digest. 105(3): 138-143 .
  • Romina Comín, Laura A. Reyna Musso, Mariana P. Cid, Carlos R. Oldani y Nancy A. Salvatierra (2013) “Citotoxicidad de Hidroxiapatita y su morfología en composites con Ti”. IEEE LATIN AMERICA TRANSACTIONS 11(1):103-105 .